The Falls of the Ohio Foundation celebrates the following historical designations:
- 1966 – National Natural Landmark
- 1974 – George Rogers Clark Home Site – National Register of Historic Places
- 1981 – National Wildlife Conservation Area (1,404 acres)
- 1990 – Indiana State Park
- 1994 – Interpretive Center
- 2002 – Lewis & Clark National Historic Trail Site
- 2006 – A Kentucky Treasure
- 2008 – One of the 7 Wonders of Louisville
- National Geographic listing in the top 200 state parks in the U.S.
- 2019 – Lewis & Clark National Historic Trail Eastern Legacy Official Trail Stop